COPASI: Support/Change History/COPASI 4 0 19 development

Assignment and ODE rules are now available for global quantities.
New optimization methods Nelder & Mead and Simulated Annealing.
The user is now able to control the weights used in parameter estimation.
The user has now direct control of the starting values for parameter estimation and optimization.
Export in XPPAUT format.
Improved editing of mathematical expression avoids input errors.
The optimization and parameter estimation tasks display now a count of adjustable parameters.
Added a message box displaying problems which COPASI may have encountered when starting the GUI application.

Fixed interface of elementary flux modes to allow scheduling of the task and printing of results including a total count of flux modes.
Improved table display of functions, which had line breaks in their mathematical expression.
Improved layout of experimental data dialog.
Fixed crash caused by committing an invalid expression for a function.
Fixed problem assigning kinetic function to reaction with non integer stoichiometry.
The display status (shown/hidden) of a curve in a plot is no preserved when a task is rerun.
Fixed crash when a product appeared as a parameter for the kinetic function in a irreversible reaction.
Fixed crash caused by sliders referring to no longer existing objects.
Fixed Madonna export of time parameter for explicitly time dependent models.
Improved check before deleting objects like compartments or metabolites to avoid crashes.
Fixed crashes related to viewing outdated results, which have been obtained through task execution before the model has been changed.
Improved SBML import of function definitions.
Fixed international character support in all filenames.
Fixed crash of stochastic simulation for empty models.

COPASI 4.0.19 (development)