The forth and fifth column contain the initial and transient value of the global quantity as well as the rate of change of the value is displayed on the sixth column. The last two columns contains the mathematical expressions which may be required as long as the type is not

As with all other model elements, you can choose how you want to add a global parameter. The most convenient way is to just enter a name in an empty cell of the column termed Name.

Global Quantities Table with 3 Entries |

If you click on the name of a global quantity in the tree on the left or double click on a row of the table only the information correlated with the chosen global quantity will be displayed.

Global Quantity User Interface with ODE Rrule |

Just as compartments and species, global quantities do not have to be a constant but can be reassigned during e.g. a time course simulation depending the values of one or more model entities. In order to specify whether a parameter has a constant value or the value is calculated on the fly according to a mathematical expression, the drop down list called Simulation Type should be used.

The drop down list contains three following entries:

Name | Description |

fixed | the value of the parameter is constant (which corresponds to the given initial value) |

assignment | the value of the parameter is determined by evaluating the given mathematical expression |

ode | the rate of change of the parameters value is determined by an ordinary differential equation |

If you want the parameters value to be calculated from a given mathematical expression you select the entry called

Not only the transient value of a parameter can be specified as a mathematical expression, but also the initial value of the parameter. If you want do specify such a mathematical expression for the initial volume of a compartment, check the check box called Use Initial Expression. An initial expression can only be specified if the Simulation Type drop down list is either set to

Global Quantity Widget with an Initial Assignment |

The mathematical expressions that can be specified for rules and initial assignments may contain the same elements as the expressions used to defined function definitions. For a detailed description of the elements see User Defined Functions. When it comes to referencing values of other model entities within mathematical expressions, there is a slight difference between the mathematical expression for a rule and that for an initial assignment. The former may reference transient values of other model entities whereas the latter may only reference initial values of other model entities.

Even so COPASI does not support building models from ordinary differential equations, one can specify a model as a set of differential equations using a set of global parameters which have the type ode.