COPASI

COPASI's Use In Biotechnology

2025
Espinel-Ríos S, Montaño López J, Avalos JL (2025) Omics-driven hybrid dynamic modeling of bioprocesses with uncertainty estimation. Biochemical Engineering Journal 216:109637 Biotechnology Genomics Computational Method Link
Kumsuwan S, Tothong C, Limmongkon A, Subsoontorn P (2025) Development and Applications of a Kinetic Model for Resveratrol Production in Escherichia coli Cell Factories. Trends in Sciences 22:9529 Metabolism Microbiology Biotechnology Link

2 publications
2024
Khanijou JK, Hee YT, Selvarajoo K (2024) Identifying Key In Silico Knockout for Enhancement of Limonene Yield Through Dynamic Metabolic Modelling. In: Bizzarri M (ed) Systems Biology. Springer US: New York, NY, 3–19. Biotechnology Metabolism Link
Khanijou JK, Hee YT, Scipion CPM, Chen X, Selvarajoo K (2024) Systems biology approach for enhancing limonene yield by re-engineering Escherichia coli. npj Systems Biology and Applications 10:1–14 Biotechnology Synthetic Biology Metabolism Link
Sigg A, Klimacek M, Nidetzky B (2024) Pushing the boundaries of phosphorylase cascade reaction for cellobiose production I: Kinetic model development. Biotechnology and Bioengineering 121:580–592 Biotechnology Metabolism Link
Sigg A, Klimacek M, Nidetzky B (2024) Pushing the boundaries of phosphorylase cascade reaction for cellobiose production II: Model-based multiobjective optimization. Biotechnology and Bioengineering 121:566–579 Biotechnology Metabolism Link
Wei X, Yang X, Hu C, Li Q, Liu Q, Wu Y, Xie L, Ning X, Li F, Cai T, Zhu Z, Zhang Y-HPJ, Zhang Y, Chen X, You C (2024) ATP-free in vitro biotransformation of starch-derived maltodextrin into poly-3-hydroxybutyrate via acetyl-CoA. Nature Communications 15:3267 Metabolism Biotechnology Link

5 publications
2023
Chilmeran M, Hodges M, Ni X-W (2023) A kinetic study of biotransformation from valencene to nootkatone in an oscillatory baffled reactor. Journal of Chemical Technology & Biotechnology 98:1356–1364 Biotechnology Link
Das N, Das A, Das S, Bhatawadekar V, Pandey P, Choure K, Damare S, Pandey P (2023) Petroleum Hydrocarbon Catabolic Pathways as Targets for Metabolic Engineering Strategies for Enhanced Bioremediation of Crude-Oil-Contaminated Environments. Fermentation 9:196 Biotechnology Environmental Sciences Link
Espinel-Ríos S (2023) Modeling, optimization, and predictive control for metabolic cybergenetics. Ph.D. Thesis, Otto-von-Guericke Universität Magdeburg, Germany Biotechnology Metabolism Link
Huber N, Alcalá-Orozco EA, Rexer T, Reichl U, Klamt S (2023) Model-based optimization of cell-free enzyme cascades exemplified for the production of GDP-fucose. Metabolic Engineering 81:10–25 Biotechnology Metabolism Link
Neiburga KD, Muiznieks R, Zake DM, Pentjuss A, Komasilovs V, Rohwer JM, Tissier A, Stalidzans E (2023) Total optimization potential (TOP) approach based constrained design of isoprene and cis-abienol production in A. thaliana. Biochemical Engineering Journal 190:108723 Metabolism Biotechnology Plant Biology Link

5 publications
2022
Anand S, Padmanabhan P, Sahu SS, Mukherjee K (2022) ANN based process optimization for the growth kinetic study of Nostoc ellipsosporum NCIM 2786. IFAC-PapersOnLine 55:423–428 Microbiology Biotechnology Link
Berzins K, Muiznieks R, Baumanis MR, Strazdina I, Shvirksts K, Prikule S, Galvanauskas V, Pleissner D, Pentjuss A, Grube M, Kalnenieks U, Stalidzans E (2022) Kinetic and Stoichiometric Modeling-Based Analysis of Docosahexaenoic Acid (DHA) Production Potential by Crypthecodinium cohnii from Glycerol, Glucose and Ethanol. Marine Drugs 20:115 Metabolism Microbiology Biotechnology Environmental Sciences Link
He Y, Li K, Wang J, Xu L, Yan J, Yang M, Yan Y (2022) A novel strategy for biodiesel production by combination of liquid lipase, deep eutectic solvent and ultrasonic-assistance in scaled-up reactor: Optimization and kinetics. Journal of Cleaner Production 372:133740 Enzymology Biotechnology Link
Kathan M, Crespi S, Thiel NO, Stares DL, Morsa D, de Boer J, Pacella G, van den Enk T, Kobauri P, Portale G, Schalley CA, Feringa BL (2022) A light-fuelled nanoratchet shifts a coupled chemical equilibrium. Nature Nanotechnology 17:159–165 Chemistry Biotechnology Macromolecular Biochemistry Link
Liu Y, Wang W, Zeng A-P (2022) Biosynthesizing structurally diverse diols via a general route combining oxidative and reductive formations of OH-groups. Nature Communications 13:1595 Biotechnology Synthetic Biology Link
Paranaiba O, Oliveira P, Marks R, Novy G, Vieira M, Luz LO, Silva PA, Ferreira R, Ramirez J, Nacif JA, Caporali G (2022) Design Automation for Emerging Technologies. Journal of Integrated Circuits and Systems 17:1–11 Biotechnology Nanotechnology Link

6 publications
2021
Arya S, Williams A, Reina SV, Knapp CW, Kreft J-U, Hobman JL, Stekel DJ (2021) Towards a general model for predicting minimal metal concentrations co-selecting for antibiotic resistance plasmids. Environmental Pollution 275:116602 Microbiology Biotechnology Environmental Sciences Link
Farinelli G, Di Luca A, Kaila VRI, MacLachlan MJ, Tiraferri A (2021) Fe-chitosan complexes for oxidative degradation of emerging contaminants in water: Structure, activity, and reaction mechanism. Journal of Hazardous Materials 408:124662 Biotechnology Chemistry Link
Hellgren J (2021) Engineering central carbon metabolism with phosphoketolase pathways in Saccharomyces cerevisiae. Ph.D. Thesis, Chalmers University of Technology, Sweden. Metabolism Biotechnology Link
Klimacek M, Zhong C, Nidetzky B (2021) Kinetic modeling of phosphorylase-catalyzed iterative β-1,4-glycosylation for degree of polymerization-controlled synthesis of soluble cello-oligosaccharides. Biotechnology for Biofuels and Bioproducts 14:134 Biotechnology Enzymology Link
Oliveira A, Rodrigues J, Ferreira EC, Rodrigues L, Dias O (2021) A kinetic model of the central carbon metabolism for acrylic acid production in Escherichia coli. PLOS Computational Biology 17:e1008704 Biotechnology Metabolism Link
Sigg A, Klimacek M, Nidetzky B (2021) Three-level hybrid modeling for systematic optimization of biocatalytic synthesis: α-glucosyl glycerol production by enzymatic trans-glycosylation from sucrose. Biotechnology and Bioengineering 118:4028–4040 Biotechnology Metabolism Link

6 publications
2020
Balasubramanian S, Chandrasekran P, Yesudhas AJR, Ganapathyraman P, Eiteman MA, Subramanian R (2020) In vivo interpretation of model predicted inhibition in acrylate pathway engineered Lactococcus lactis. Biotechnology and Bioengineering 117:3785–3798 Microbiology Metabolism Biotechnology Link
Ćorović M, Milivojević A, Simović M, Banjanac K, Pjanović R, Bezbradica D (2020) Enzymatically derived oil-based L-ascorbyl esters: Synthesis, antioxidant properties and controlled release from cosmetic formulations. Sustainable Chemistry and Pharmacy 15:100231 Biotechnology Link
Fuchino K, Kalnenieks U, Rutkis R, Grube M, Bruheim P (2020) Metabolic Profiling of Glucose-Fed Metabolically Active Resting Zymomonas mobilis Strains. Metabolites 10:E81 Metabolism Microbiology Biotechnology Link
Zhou Q, Liu Y, Yuan W (2020) Kinetic modeling of butyric acid effects on butanol fermentation by Clostridium saccharoperbutylacetonicum. New Biotechnology 55:118–126 Biotechnology Microbiology Link

4 publications
2019
Nguyen VD, Styevkó G, Madaras E, Haktanirlar G, Tran ATM, Bujna E, Dam MS, Nguyen QD (2019) Immobilization of β-galactosidase on chitosan-coated magnetic nanoparticles and its application for synthesis of lactulose-based galactooligosaccharides. Process Biochemistry 84:30–38 Biotechnology Link
Tapia F, Laske T, Wasik MA, Rammhold M, Genzel Y, Reichl U (2019) Production of defective interfering particles of influenza A virus in parallel continuous cultures at two residence times–insights from qPCR measurements and viral dynamics modeling. Frontiers in Bioengineering and Biotechnology 7:275 Biotechnology Link

2 publications
2018
Nguyen VD, Styevkó G, Ta LP, Tran ATM, Bujna E, Orbán P, Dam MS, Nguyen QD (2018) Immobilization and some properties of commercial enzyme preparation for production of lactulose-based oligosaccharides. Food and Bioproducts Processing 107:97–103 Biotechnology Enzymology Link
Palai T, Bhattacharya PK (2018) Bioconjugates from smart polymers and β-galactosidase: Synthesis, characterization and application in producing galacto-oligosaccharides from lactose. Journal of Indian Chemical Society 95:917–924 Biotechnology Link
Vranish JN, Ancona MG, Oh E, Susumu K, Lasarte Aragonés G, Breger JC, Walper SA, Medintz IL (2018) Enhancing Coupled Enzymatic Activity by Colocalization on Nanoparticle Surfaces: Kinetic Evidence for Directed Channeling of Intermediates. ACS Nano 12:7911–7926 Biotechnology Enzymology Link
Wang M, Wölfer C, Otrin L, Ivanov I, Vidaković-Koch T, Sundmacher K (2018) Transmembrane NADH Oxidation with Tetracyanoquinodimethane. Langmuir 34:5435–5443 Biochemistry Biotechnology Link
Zhou Q, Liu Y, Yuan W (2018) Kinetic modeling of lactic acid and acetic acid effects on butanol fermentation by Clostridium saccharoperbutylacetonicum. Fuel 226:181–189 Metabolism Microbiology Biotechnology Link

5 publications
2017
Komasilovs V, Pentjuss A, Elsts A, Stalidzans E (2017) Total enzyme activity constraint and homeostatic constraint impact on the optimization potential of a kinetic model. BioSystems 162:128-134 Computational Method Biotechnology Link
Milivojević A, Ćorović M, Carević M, Banjanac K, Vujisić L, Veličković D, Bezbradica D (2017) Highly efficient enzymatic acetylation of flavonoids: Development of solvent-free process and kinetic evaluation. Biochemical Engineering Journal 128:106–115 Biotechnology Enzymology Link
Stalidzans E, Mozga I, Sulins J, Zikmanis P (2017) Search for a Minimal Set of Parameters by Assessing the Total Optimization Potential for a Dynamic Model of a Biochemical Network. IEEE/ACM Transactions on Computational Biology and Bioinformatics 14:978–985 Computational Method Biotechnology Link
Vranish JN, Ancona MG, Oh E, Susumu K, Medintz IL (2017) Enhancing coupled enzymatic activity by conjugating one enzyme to a nanoparticle. Nanoscale 9:5172–5187 Enzymology Biotechnology Link

4 publications
2016
Firdaus MY, Brask J, Nielsen PM, Guo Z, Fedosov SN (2016) Kinetic model of biodiesel production catalyzed by free liquid lipase from Thermomyces lanuginosus. Journal of Molecular Catalysis B: Enzymatic 133:55–64 Biotechnology Enzymology Link
Firdaus MY, Guo Z, Fedosov SN (2016) Development of kinetic model for biodiesel production using liquid lipase as a biocatalyst, esterification step. Biochemical Engineering Journal 105:52–61 Biotechnology Link
Palai T, Kumar A, Bhattacharya PK (2016) Enzyme immobilization/bioconjugation in producing galactio-oligosaccharidies from lactose: developments of kinetic models and bio-reactors. Materials Today: Proceedings 3:3568–3586 Biotechnology Link
Salcedo-Sora JE, Mc Auley MT (2016) A mathematical model of microbial folate biosynthesis and utilisation: implications for antifolate development. Molecular BioSystems 12:923–933 Microbiology Metabolism Biotechnology Link

4 publications
2015
Kashyap R, Palai T, Bhattacharya PK (2015) Kinetics and model development for enzymatic synthesis of fructo-oligosaccharides using fructosyltransferase. Bioprocess and Biosystems Engineering 38:2417-26 Biotechnology Metabolism Link
Maggi M, Chiarelli LR, Valentini G, Scotti C (2015) Engineering of Helicobacter pylori L-asparaginase: characterization of two functionally distinct groups of mutants. PLOS One 10:e0117025 Microbiology Biotechnology Enzymology Link
Palai T, Kumar A, Bhattacharya PK (2015) Kinetic studies and model development for the formation of galacto-oligosaccharides from lactose using synthesized thermo-responsive bioconjugate. Enzyme and Microbial Technology 70:42-49 Biotechnology Enzymology Link
Raganati F, Procentese A, Olivieri G, Götzc P, Salatino P, Marzocchella A (2015) Kinetic study of butanol production from various sugars by Clostridium acetobutylicum using a dynamic model. Biochemical Engineering Journal 99:156-66. Biotechnology Metabolism Microbiology Link
Trausinger G, Gruber C, Krahulec S, Magnes C, Nidetzky B, Klimacek M (2015) Identification of novel metabolic interactions controlling carbon flux from xylose to ethanol in natural and recombinant yeasts. Biotechnology for Biofuels and Bioproducts 8:157 Biotechnology Metabolism Link

5 publications
2014
Khandekar DC, Palai T, Agarwal A, Bhattacharya PK (2014) Kinetics of sucrose conversion to fructo-oligosaccharides using enzyme (invertase) under free condition. Bioprocess and Biosystems Engineering 37:2529–2537 Enzymology Biotechnology Link
Palai T, Singh AK, Bhattacharya PK (2014) Enzyme, beta-galactosidase immobilized on membrane surface for galacto-oligosaccharides formation from lactose: kinetic study with feed flow under recirculation loop. Biochemical Engineering Journal 88:68-76 Biotechnology Enzymology Link
Raganati F (2014) Butanol production by fermentation of renewable feedstocks. Ph.D. Thesis, Università di Napoli Federico II, Naples, Italy Biotechnology Link

3 publications
2013
Altintaş CM (2013) Effects of growth medium conditions on antibiotic production by actinomyces sp. MS Thesis, Dokuz Eylül University, Izmir, Turkey Biotechnology Microbiology Link
Fedosov SN, Brask J, Pedersen AK, Nordblad M, Woodley JM, Xu X (2013) Kinetic model of biodiesel production using immobilized lipase Candida antarctica lipase B. Journal of Molecular Catalysis B: Enzymatic 85–86:156–168 Biotechnology Enzymology Link

2 publications
2012
Altintaş CM, Ertas G, Kayali HA (2012) Simulation of Microbial Production of Ramoplanin via Stoichiometric Modeling from Actinoplanes sp. ATCC 33076. New Biotechnology 29:S144–S145 Microbiology Biotechnology Link

1 publication
2011
Casas A, Ramos MJ, Pérez Á (2011) Kinetics of chemical interesterification of sunflower oil with methyl acetate for biodiesel and triacetin production. Chemical Engineering Journal 171:1324–1332 Biotechnology Chemistry Link
Fedosov SN, Xu X (2011) Enzymatic synthesis of biodiesel from fatty acids. Kinetics of the reaction measured by fluorescent response of Nile Red. Biochemical Engineering Journal 56:172–183 Biotechnology Link

2 publications
2010
Escuela G, Hinze T, Dittrich P, Schuster S, Moreno-Alvarez M (2010) Modelling Modified Atmosphere Packaging for Fruits and Vegetables using Membrane Systems. In Fred A, Filipe J Gamboa H. (Eds.), Proc. 3rd International Conference on Bio-inspired Systems and Signal Processing BIOSIGNALS 2010, pp. 306-311, INSTICC press Computational Method Biotechnology Link
Mellor N, Bligh F, Chandler I, Hodgman C (2010) Reduction of Off-Flavor Generation in Soybean Homogenates: A Mathematical Model. Journal of Food Science 75:R131–R138 Metabolism Biotechnology Link

2 publications
2009

0 publication
2008
Lagzdina L, Mozga I, Stalidzans E (2008) Algorithm for bioethanol yield optimisation in Saccharomyces cerevisiae glycolysis using “COPASI.” Paper presented at the International Scientific Conference: Applied Information and Communication Technologies, , Jelgava (Latvia), 10-12 Apr 2008. Latvia University of Agriculture. Biotechnology Link

1 publication
2007

0 publication
2006

0 publication
2005

0 publication