A new stable release COPASI 4.5 (Build 30) is now available.

COPASI 4.5 (Build 30) Released

COPASI 4.5 (Build 30), which is a part of our stable release series, has been made available for download on April 14, 2009. A list of improvements and resolved issues can be found in the changelog for this release. Access to the packages is provided in our non-commercial or commercial download areas. Every user including those using development releases are strongly encouraged to update to this new stable release.

New Features since COPASI 4.4 (Build 26)

• Graphical User Interface (CopasiUI)
  • MIRIAM compliant annotation for the model, species, compartments, reactions, global quantities, and kinetic functions. For details about this new feature please see the technical documentation for MIRIAM Annotation.
  • Added time scale separation task.
  • The correct number of substrates and products is only enforced for kinetic functions which are classified as being reversible or irreversible. This means the list of valid functions shows now all functions which are classified as unrestricted.
  • COPASI can display graphical layouts of the reaction network. It is able to overlay simulation results of time courses onto them. Layouts can be imported through SBML files which contain them in the SBML layout extension format. The COPASI file format preserves this layout information.
  • Added information to the to the Time Course task displaying the integration and output interval.
  • Added 3D bar chart display to all color coded matrices.
  • Enhanced the object selection dialog to support selecting individual matrix elements.
  • COPASI is now able to exchange SBML models with the SystemsBiology Workbench. The exchange of models works in both directions.
  • The initial time for autonomous models is set and kept at 0. Autonomous models are models which do not depend explicitly on time, i.e., time does not appear in any rate law, ODE, or assignment.
  • The COPASI specific file dialog has been replaced with the standard dialog of the operating system COPASI is running on.
  • It is now possible to save plots as well as the main widget in the png graphic format. This feature provides an additional way to preserve the results.
  • It is now possible to hide or show all curves within one plot by clicking a single button.
  • The results for the optimization task now feature an update button which allows the user to modify the model.
  • Added save button to the result of the elementary flux mode task.
  • Added save button to the parameter overview.
  • Local reaction parameters can now be selected in mathematical expressions for initial assignments, assignments, and ODEs.
  • COPASI supports now dimensionless units.
• Simulation Engine
  • Added time scale separation analysis.
  • We added the capability to use matrix elements in mathematical formulas. This enables e.g. optimization of control coefficients.
  • Scans of optimizations and parameter estimation calculations are now possible.
• SBML
  • COPASI imports the invalid RDF/XML used in SBML Level 2 Versions 2-3. The SBML Level 2 Version 4 specification resolves this issue but is not yet supported by COPASI.
  • MIRIAM annotation is now exported to SBML as valid RDF in the COPASI name space in the annotation element and as invalid RDF/XML required in SBML Level 2 Versions 2-3.