COPASI 4.46 (Build 300)

Version 4.45.300

Release Date: January 23, 2026

New Features since COPASI 4.45 (Build 298)

• Graphical User Interface (CopasiUI)
  • Parameter Estimation: Start in Steady State can now be selected per experiment..

Bug Fixes and Enhancements since COPASI 4.45 (Build 298)

• Graphical User Interface (CopasiUI)
  • Parameter Overview: Fixed crash occurring when changing local reaction parameters.
  • Optimization and Parameter Estimation: Fixed editing Display Population checkbox.
  • Global Quantity: Fixed potential crash when copying of a global quantity with an assignment containing a piece wise expression.
  • Load Parameter Sets: Fixed crash when loading additional parameter sets stored in a separate file.
  • Reactions: Fixed mapping of 2 substrate kinetics for reactions of the form 2 * Y -> ...
  • Functions: Fixed copying of functions containing notes.
• Simulation Engine
  • Time Course: Fixed problem with event triggers evaluating to NaN.
  • Time Course: Improved root finding to determine event firing.
  • Time Course: Fixed initial event detection if the Start in Steady State is selected.
  • Time Course: Fixed detection of non integer stoichiometry for stochastic or hybrid algorithms.
  • Optimization and Parameter Estimation: Reaction parameters mapped to global quantities were not correctly loaded.
  • Scan: Fixed behavior of Continue from Current State.
  • JIT Compilation: Fixed crash occurring occasionally on Windows.
Standards
• COMBINE Archive: Fixed naming of experiment data files for Parameter Estimation.
• SBML: Assure that the selected render information is exported.