COPASI

COPASI's Use In Genetics

2025
Bhat GS, Shaik Mohammad AF (2025) Mechanistic Modeling the Role of MicroRNAs and Transcription Factors in Disease Progression. In: Lai X, Gupta S and Vera Gonzalez J (eds) Computational Biology of Non-Coding RNA. Springer US: New York, NY, 195–230. Genetics Computational Method Link
Delaforge E, Due AD, Theisen FF, Morffy N, O’Shea C, Blackledge M, Strader LC, Skriver K, Kragelund BB (2025) Allovalent scavenging of activation domains in the transcription factor ANAC013 gears transcriptional regulation. Nucleic Acids Research 53:gkaf065 Genetics Plant Biology Link
Dong J, Sathyan KM, Scott TG, Mukherjee R, Guertin MJ (2025) ZNF143 binds DNA and stimulates transcription initiation to activate and repress direct target genes. Nucleic Acids Research 53:gkae1182 Genetics Genomics Link
Harika GL, Sriram K (2025) Kinetic modelling reveals the presence of multistability in normal and stressful conditions in translational initiation mechanism. PLOS One 20:e0319280 Biochemistry Genetics Link

4 publications
2024
An H, Pires JC, Conant GC (2024) Gene expression bias between the subgenomes of allopolyploid hybrids is an emergent property of the kinetics of expression. PLOS Computational Biology 20:e1011803 Genetics Genomics Link
Patel K, Barter M, Soul J, Clark P, Proctor CJ, Clark I, Young D, Shanley DP (2024) Systems analysis of miR-199a/b-5p and multiple miR-199a/b-5p targets during chondrogenesis. eLife 12:RP89701 Genetics Link

2 publications
2023
Mendes P (2023) Reproducibility and FAIR principles: the case of a segment polarity network model. Frontiers in Cell and Developmental Biology 11:1201673 Genetics Signaling Computational Method Link
Pozdnyakov EM, Korneichuk AD, Rogacheva AV, Vasilev GA (2023) Polymerase β Limits the Rate of DNA Single-Strand Break Repair. Mathematical Biology and Bioinformatics 18:294–307 Genetics Biochemistry Link
Tare P, Bhowmick T, Katagi G, China A, Nagaraja V (2023) Comparison of Transcription Elongation Rates of Three RNA Polymerases in Real Time. ACS Omega 8:47510–47519 Genetics Macromolecular Biochemistry Link

3 publications
2022
Gulhane P, Nimsarkar P, Kharat K, Singh S (2022) Deciphering miR-520c-3p as a probable target for immunometabolism in non-small cell lung cancer using systems biology approach. Oncotarget 13:725–746 Genetics Link
Abbas-Chakhtoura J, Chinchilla-Monge R, Mora-Rodríguez R (2022) mi-RNA129-1 and mi-RNA24-2 as regulators of over-expressed genes in lung typical carcinoid tumors: Potential targets for molecular therapy. Proceedings of the 2022 IEEE 4th International Conference on BioInspired Processing (BIP), 1–8 Genetics Link
Valverde MB, Mora-Rodríguez R (2022) miRNA networks regulating gene expression in response to tension or compression forces in the cells of the periodontal ligament. 2022 IEEE 4th International Conference on BioInspired Processing (BIP), Cartago, Costa Rica: 1–6 Genetics Link

3 publications
2021
Acón M, Geiß C, Torres-Calvo J, Bravo-Estupiñan D, Oviedo G, Arias-Arias JL, Rojas-Matey LA, Baez E, Vásquez-Vargas G, Oses-Vargas Y, Guevara-Coto J, Segura-Castillo A, Siles-Canales F, Quirós-Barrantes S, Régnier-Vigouroux A, Mendes P, Mora-Rodríguez R (2021) MYC dosage compensation is mediated by miRNA-transcription factor interactions in aneuploid cancer. iScience 24:103407 Genetics Biochemistry Computational Method Link
Chushak Y, Harbaugh S, Zimlich K, Alfred B, Chávez J, Kelley-Loughnane N (2021) Characterization of synthetic riboswitch in cell-free protein expression systems. RNA Biology 18:1727-1738 Biochemistry Genetics Link

2 publications
2020
Arya S, Todman H, Baker M, Hooton S, Millard A, Kreft J-U, Hobman JL, Stekel DJ (2020) A generalised model for generalised transduction: the importance of co-evolution and stochasticity in phage mediated antimicrobial resistance transfer. FEMS Microbiology Ecology 96:fiaa100 Microbiology Genetics Link
Carlson-Stevermer J, Das A, Abdeen AA, Fiflis D, Grindel BI, Saxena S, Akcan T, Alam T, Kletzien H, Kohlenberg L, Goedland M, Dombroe MJ, Saha K (2020) Design of efficacious somatic cell genome editing strategies for recessive and polygenic diseases. Nature Communications 11:6277 Laboratory Method Genetics Link
Greiss F, Daube SS, Noireaux V, Bar-Ziv R (2020) From deterministic to fuzzy decision-making in artificial cells. Nature Communications 11:5648 Synthetic Biology Genetics Link

3 publications
2019
Anderson R, Lagnado A, Maggiorani D, Walaszczyk A, Dookun E, Chapman J, Birch J, Salmonowicz H, Ogrodnik M, Jurk D, Proctor CJ, Correia-Melo C, Victorelli S, Fielder E, Berlinguer-Palmini R, Owens A, Greaves LC, Kolsky KL, Parini A, Douin-Echinard V, LeBrasseur NK, Arthur HM, Tual-Chalot S, Schafer MJ, Roos CM, Miller JD, Robertson N, Mann J, Adams PD, Tchkonia T, Kirkland JL, Mialet-Perez J, Richardson GD, Passos JF (2019) Length-independent telomere damage drives post-mitotic cardiomyocyte senescence. EMBO Journal 38:e100492 Genetics Physiology Link
Lebar T, Verbič A, Ljubetič A, Jerala R (2019) Polarized displacement by transcription activator-like effectors for regulatory circuits. Nature Chemical Biology 15:80–87 Synthetic Biology Genetics Link

2 publications
2018
Buriticá DCC, Mejía BV, Rojas LM, Sáenz L, Yosa J (2018) Análisis determinístico de la red de regulación génica involucrada en la expresión y función del factor de transcripción σ^ 32 en E. coli. Revista Cuarzo 23:7–15 Genetics Microbiology Link
Yeom K-H, Mitchell S, Linares AJ, Zheng S, Lin C-H, Wang X-J, Hoffmann A, Black DL (2018) Polypyrimidine tract-binding protein blocks miRNA-124 biogenesis to enforce its neuronal-specific expression in the mouse. Proceedings of the National Academy of Sciences USA 115:E11061–E11070 Genetics Biochemistry Link

2 publications
2017
Orlenko A, Chi PB, Liberles DA (2017) Characterizing the roles of changing population size and selection on the evolution of flux control in metabolic pathways. BMC Evolutionary Biology 17:117 Biochemistry Genetics Link
Proctor CJ, Goljanek-Whysall K (2017) Using computer simulation models to investigate the most promising microRNAs to improve muscle regeneration during ageing. Scientific Reports 7:12314 Genetics Signaling Link
Proctor CJ, Smith GR (2017) Computer simulation models as a tool to investigate the role of microRNAs in osteoarthritis. PLOS One 12:e0187568 Genetics Signaling Link

3 publications
2016
Boross G, Papp B (2016) No evidence that protein noise-induced epigenetic epistasis constrains gene expression evolution. Molecular Biology and Evolution 34:380–390 Metabolism Genetics Link
Chizzolini F (2016) The relationship between genotype and phenotype in cell-free transcription-translation reactions. Ph.D. Thesis, University of Trento, Italy Genetics Link
Lloréns-Rico V, Cano J, Kamminga T, Gil R, Latorre A, Chen W-H, Bork P, Glass JI, Serrano L, Lluch-Senar M (2016) Bacterial antisense RNAs are mainly the product of transcriptional noise. Science Advances 2:e1501363 Microbiology Genetics Link
Orlenko A, Teufel AI, Chi PB, Liberles DA (2016) Selection on metabolic pathway function in the presence of mutation-selection-drift balance leads to rate-limiting steps that are not evolutionarily stable. Biology Direct 11:31 Genetics Metabolism Link
Pires JC, Conant GC (2016) Robust yet fragile: expression noise, protein misfolding, and gene dosage in the evolution of genomes. Annual Review of Genetics 50:113–131 Genetics Genomics Link
Rantasalo A, Czeizler E, Virtanen R, Rousu J, Lähdesmäki H, Penttilä M, Jäntti J, Mojzita D (2016) Synthetic Transcription Amplifier System for Orthogonal Control of Gene Expression in Saccharomyces cerevisiae. PLOS One 11:e0148320 Genetics Microbiology Synthetic Biology Link

6 publications
2015
Dornseifer S, Willkomm S, Far RK, Liebschwager J, Beltsiou F, Frank K, Laufer SD, Martinetz T, Sczakiel G, Claussen JC, Restle T (2015) RNAi revised - target mRNA-dependent enhancement of gene silencing. Nucleic Acids Research 43:10623-32. Macromolecular Biochemistry Genetics Link
Mandlik V, Gurav M, Singh S (2015) Regulatory dynamics of network architecture and function in tristable genetic circuit of Leishmania: a mathematical biology approach. Journal of Biomolecular Structure and Dynamics 33:2554-62 Synthetic Biology Genetics Metabolism Parasitology Link
Rastgou Talemi S, Kollarovic G, Lapytsko A, Schaber J (2015) Development of a robust DNA damage model including persistent telomere-associated damage with application to secondary cancer risk assessment. Scientific Reports 5:13540 Genetics Macromolecular Biochemistry Link

3 publications
2014
Ryll A, Bucher J, Bonin A, Bongard S, Gonçalves E, Saez-Rodriguez J, Niklas J, Klamt S (2014) A model integration approach linking signalling and gene-regulatory logic with kinetic metabolic models. BioSystems 124:26–38 Metabolism Signaling Genetics Link

1 publication
2013

0 publication
2012
Ray JCJ, Igoshin OA (2012) Interplay of Gene Expression Noise and Ultrasensitive Dynamics Affects Bacterial Operon Organization. PLOS Computational Biology 8:e1002672 Microbiology Genetics Link

1 publication
2011
Li Y, Cucinotta FA (2011) Modeling non-homologous end joining. Journal of Theoretical Biology 283:122–135 Genetics Theory Macromolecular Biochemistry Link

1 publication
2010
Smith GR, Shanley DP (2010) Modelling the Response of FOXO Transcription Factors to Multiple Post-Translational Modifications Made by Ageing-Related Signalling Pathways. PLOS One 5:e11092 Signaling Genetics Link
Tiwari A, Balázsi G, Gennaro ML, Igoshin OA (2010) The interplay of multiple feedback loops with post-translational kinetics results in bistability of mycobacterial stress response. Physical Biology 7:36005 Microbiology Genetics Link

2 publications
2009
Kovács K, Hurst LD, Papp B (2009) Stochasticity in Protein Levels Drives Colinearity of Gene Order in Metabolic Operons of Escherichia coli. PLOS Biology 7:e1000115 Genetics Link

1 publication
2008

0 publication
2007

0 publication
2006

0 publication
2005

0 publication